That will never happen but I gotta be honest in this one case I'd be happy if it did. Misaki has it so easy with Usagi. Usagi puts up with so much for him. I would not be able to take the stress and anxiety. He's basically a love martyr.
That's such a shared sentiment the japanese have started making doujinshi where some OCs steal Nakamura sensei's semes' hearts by making love to them
http://aarinfantasy.com/forum/attachments/f140/167652d1430493174-tmp_31655-pixiv50118708_1-1661959220.jpg
It'd be real funny if Misaki just moved out presuming Usagi will be fine even after 4 years of living with a flicky, indecisive partner such as Misaki and Usagi in retaliation for being wounded just started a relationship with someone else.