Devastating last page/s (short, mostly BL)

Oneshot ch.6
Set during the Edo period. Mistaking his next target, samurai Hirata meets Shirase, a student whose teacher is in prison, suspected of working for the bakufu (rival faction).
Tragedy
Tearjerker

Oneshot ch.1+5
from Tep:
A baby found in the red district and raised by prostitutes. Though survival is hard to cope up, he tries to strive for his fragile dream to become a doctor. Despite the bitterness that is being slowly mold in his heart, he always wait for this doctor to pay visit to him.
The continuing in Ch.5, Kiyohito's life becomes epic.
Very sad ending

[from Eldalote:] A gay man breaks it of with his lover when he enters an arranged marriage. A really sad story, mostly because it depicts the reality for many people. (Manwha, read from left to right)
Non happy ending
Tearjerker

Though an open-ending, the way the uke discovered his own feelings was really hard.