IS (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. IS stands for Inter Sexuality.
This manga deals with very serious issues concerning intersexual people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga.
Nozomi Aizawa has has kept her feelings for her schoolmate Azuma-kun a secret for quite a while, but the time has come for her to finally confess. His response, though, is far from ordinary! Led in circles by his hilarious tangents, these two awkward teenagers find themselves growing ever closer while muddling through misunderstandings and off-topic rants.
Tsutsui Hikari is an otaku, and he mostly avoids social life. Hikari has only one friend at school, who is also a social misfit, and he is mocked brutally by most of his classmates for being creepy and weird. One day, he ends up having to clean the school pool with Igarashi Iroha, who appears to be pretty much everything he hates in real-life girls. She skips school, has a blunt manner, doesn't have female friends, and seems the sort to be promiscuous.
Kang Chan and Seyeon have been close friends since they were young after being introduced by their parents. After entering high school, Seyeon suddenly received a confession from Kang Chan and became aware of Kang Chan since then. Meanwhile, Naeun is displeased with their relationship. The trivial and noisy story of their love triangle and those around them...
Mei Sengoku is an independent girl and captain of her high school kendo club who enjoys helping others in need. This has earned her a lot of admirers among the girls at her school, as well as a guy named Shirou Fuji well-known at school for his girly way of speaking and gestures. When Shirou asks Mei to go out with him, she simply rejects him, but he comes back the next day and tells her he's not going to give up on her so easily.
The story revolves around a innocent naive schoolgirl, Yume, who falls in love with a gorgeous ex-Yankee, Shoubu. Meanwhile, Yume s best friend, Roko, falls for Shoubu s best friend, Yuuji who is a playboy.
Eungi has been in college without being engaged with others. One day by encounter, he finds the secret of underclassman Jeongwoo. Why are you so nervous to forget? A love story that’s both easy and difficult.
Chigira Ruiji is a man born with the face of a demon. Trouble follows him wherever he goes. However, he just wants to live a normal high school life and make some friends, and even fall in love...
After his first love confession is rejected, Yuuki Shibuki finds himself crying away his heartbreak at a park. Feeling depressed and blaming his short height and feminine looks for his failure, his pain is eased when he encounters a cool, hooded street musician who has a soothing touch with the guitar.
High schoolers Yuki and Shigeru aren't dating, but still enjoy a highly active sexual relationship. Naive and still very child-like in the way they think, it comes as a great shock to them when Shigeru discovers she's pregnant. The two are confront
Is - Otoko Demo Onna Demo Nai Sei