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Since even before reincarnating, Isabella loved the side character Ursch. Now that she exists in his world, she is determined to marry him!
Melissa isn't the main lead, she's the villainess who is engaged to the crown prince, but soon after reincarnating she discovers that all four of the love interests in this novel are TERRIBLE and she is determined to save the heroine from her fate. Good thing she has this cute werewolf on her side!
Rei is reincarnated into an otome game, but she could not care less about the male leads. Forget them, she loves the villainess!
I don't think that this is isekai, but the plot is a very good fit for this list. The MC, Sharina, has a crush on a poor, studious, and gloomy guy and it seems to be reciprocated! Unfortunately, the super-annoying, narcissistic prince takes her disinterest in him as a challenge.
The MC transmigrates into the world of a romance comic, but she'd much rather date the second ML than the one she is supposed to end up with.
Olivia reincarnates as a villainess in an otome game, but instead of being interested in her fiance, she decides to pursue the butler.
Rebecca recalls her happy marriage from her last life. With a conviction event and her engagement annulled, she decides to search for her soulmate.
The Villainess Want to Marry a Commoner!!