Read the "Rules, Hydra, Lovers and Souls" series. There's unrequited love ALL UP AND DOWN DIS BYTCH!
-Shadow
Morcheeba's lists: Unrequited love-yaoi/shounen ai
http://www.mangago.me/home/mangalist/26111/
i really like this one.. hope you enjoy this too.. http://www.mangago.me/read-manga/itsuka_tomodachi_ja_nakunaru_to_shite_mo/
Try "Higouhou Junai" by Fuwa Shinri. The main/1st couple's story is like that. It's not like one of those typical yaoi where the seme immediately falls for the uke after finding about the uke's feelings. My heart wrenched for the uke several times in this manga. There's also a side story about the seme's assistant/secretary(a glasses blond guy. Sorry, can't remember his name exactly) which seems to fit your 2nd requirement.
http://www.mangago.me/read-manga/higouhou_junai/
Really heart wrenching BL about unrequited love? I'd prefer if the couple were more on the adultish side (so like college), but that isn't necessary.
Oh and can the love please be requited at the end?
Edit: if it's still unrequited at the end, the MC can the MC have a frind who liked him and they get together instead