Most of the following may not be very seinen or fit what you're looking for at all, but I'll put it here just in case..
I dunno if it was well handled but "bungou stray dogs" oyasumi punpun (classic) lookism happy sugar life Bokutachi ga Yarimashita Jagaaaaaan vinland saga (no but this is beautiful)
I wanna read something that has a lot of mental issues and real world struggles but also insanely seinen