cool comment, but:
1. it's transgenderness. "transgenderism" is a right-wing transphobe term, they believe it is a illness ("ism" is a suffix that means disease).
2. you're mixing sex and genitals...
I am a trans man in a gay relationship and we're not from opposite sexes! lmao
sex is a bundle of secondary gender characteristics that gives you a specific social reading, not genitals. I am a trans male, still socially male regardless of chromosomes. (づ ̄ ³ ̄)づ

it must be conflicting to fall in love with a transgender person as the opposite sex from them (sex, not gender), especially if they have shown interest in what would be a straight relo unrequited love hurts no matter the gender
the way i actually sobbed seeing rika (almost) fully transitioned THATS OUR SONNN
this is such a beautiful lgbtq manga i'm gonna miss it so bad ☹