Idk if you can do it generally across the whole site, but…
The closest I’ve found is when clicking on one of the overhead tabs (Yaoi, comedy, shounen ai, etc.) a whole list of tags pops up. You double click the box next to that tag to x it out or once to apply the tag. It’s a filter system. After you click ur desired and exclude ur unwanted, click the pink “okay, go” and it’ll show all manhwa manga etc, that fit that description