Okay so Yuri and Frey are on their second life after time getting turned back by Regina the girl that Yuri saved from being burned at the stake in her first life, Regina had to make some sort of sacrifice to turn back time we don't know what the sacrifice is yet. They haven't been able to find Regina yet, they did find Bliss who tried to manipulate Frey into always thinking of her and cursing him with black magic when he was a child before he met Yuri and Lysandro, the curse on Frey is just like the curse on the followers of the religion Vernbaum which is a fallen angel of trials. I think that Regina is Vernbaum, because it talked about the angel turning back time and was now recovering.