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short explanation!

chuuwrld January 28, 2026 8:18 pm

for people that are confused about the drug and Dr. Shin's explanation in ch24, i hope this helps a bit ^^

neurotransmitters are chemicals that allows our brain neurons to communicate with each other. serotonin is an NT that stabilizes our well-being, regulating our mood, sleep, etc. it's what allows us to feel satisfied.

how the Smile drug works is that it overloads the person temporarily with serotonin, leading to a period of intense euphoria and heightened senses, before destroying the serotonin receptors that would normally receive serotonin -- so there's a breakdown in communication. if your body can't receive serotonin chemicals, it leads to depression, sleep disorders, anxiety, memory loss, and more. it sounds like the Smile drug is an extreme version of molly/ecstasy, if you're familiar with that!

we have another NT called dopamine, which is known as the pleasure NT: we receive dopamine when we're doing things that make us feel good, it's like a reward, but it's only a temporary rush (compared to the long-term calmness we get with serotonin).

what Dr. Shin is suggesting is basically rerouting the serotonin away from the damaged serotonin receptors, and towards the undamaged dopamine receptors to be received alongside dopamine. IIRC, this is how some SSRIs/antidepressants work! however, it seems that normal SSRIs haven't worked on Jaeyoung. I'm not exactly sure of Seungmin's role in this, but maybe (with the power of BL logic) Seungmin's giving Jaeyoung experiences that would lead to dopamine and serotonin release while grounding him so he won't receive too much of it (because that would lead to aftereffects like with cocaine). basically, like a human SSRI?

if anyone more versed in neuroscience wants to pitch in please do so !! this is a very simplistic explanation based on my limited neuropsychology knowledge lol

Responses
    gintoki January 28, 2026 10:09 pm

    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then jaeyoung will only feel pleasure BEFORE spending time with seungmin, because the dopamine rush is tied to anticipation and expectation rather than the experience itself. which means seungmin will never witness jaeyoung at his happiest. sad, isn’t it?

    chuuwrld January 28, 2026 10:41 pm
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    that wasn't a fun fact at all i want a refund

    Ji9STAR January 29, 2026 12:02 am
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    Way to break my heart

    xzia January 29, 2026 2:50 am
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    GIRL POSTING THIS WAS A CHOICEEEE

    gintoki January 29, 2026 3:06 am
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    LMAO I’M SORRY GUYS but consider this a heads up before season 2 drops because I have a feeling it’ll be aaangsty af

    blackflaglawfirm January 29, 2026 5:04 am

    Thank you SOOO much! I was on the right track but I wasn't sure. I should probably know this because normal SSRIs didn't work on me and I needed another medicine. (⊙…⊙ )

    blackflaglawfirm January 29, 2026 5:05 am
    that wasn't a fun fact at all i want a refund chuuwrld

    Same T_T

    blackflaglawfirm January 29, 2026 5:06 am
    LMAO I’M SORRY GUYS but consider this a heads up before season 2 drops because I have a feeling it’ll be aaangsty af gintoki

    I have a feeling too T_T I will try to remain strong and marinate because ma hart can't handle angst. I need to know they're okay T_T MC has been through too much

    jistardust January 29, 2026 9:22 am
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    staring at this with a

    jistardust January 29, 2026 9:22 am
    thank you for the explanation! i’d like to add a fun fact (it’s actually a sad fact) about dopamine that wasn’t mentioned in this chapter: if seungmin ends up being the trigger of dopamine release, then j... gintoki

    staring at this with a lump in my throat rn thanks? ig