Anxious over stupid shit

My friends are like huge shit talkers, mostly for valid shit but there's like this one friend which gets pissy over a lot of small stuff lately, its not often but its often enough that it makes me think of everything I say or do is pissing them off and its horrible. She has said she has been off her meds and I feel like that might be why.
Its not like I can say anything either because they are like my bestfriend and I really want to keep this friendship because we've been friends for years and I really love being her friend, but sometimes it just feels like I have to censor myself around them?

Like I was asking another friend about what bls she reads because I learnt she read some and idk if she was joking or not (she struggles with tone) but she went 'really?' and I felt shitty because maybe I was interrupting her or something. She doesn't mind that I read bl that I know of.

She's a really great friend otherwise but like idk how to stop feeling like this or how to bring it up without feeling like I'm attacking her for it.